Polyvalent complexes for vaccine development

Living Attenuated Oral Polyvalent Dysentery Vaccine

FORMAL, SAMUEL B. (Walter Reed Army Institute of Research, Washington, D.C.), T. H. KENT, H. C. MAY, A. PALMER, AND E. H. LABREC. Protection of monkeys against experimental challenge with a living attenuated oral polyvalent dysentery vaccine. J. Bacteriol. 91:17-22. 1966.-Virulent strains of Shigella flexneri lb, S. flexneri 3, and S. sonnei I were mated with an Hfr strain of Escherichia coli K...

Ranking viruses: measures of positional importance within networks define core viruses for rational polyvalent vaccine development

MOTIVATION The extraordinary genetic and antigenic variability of RNA viruses is arguably the greatest challenge to the development of broadly effective vaccines. No single viral variant can induce sufficiently broad immunity, and incorporating all known naturally circulating variants into one multivalent vaccine is not feasible. Furthermore, no objective strategies currently exist to select ac...

Production and standardization of polyvalent Clostridium perfringens vaccine in Iran

Role of spleen in immune response to polyvalent pneumococcal vaccine.

The immune response of lymphocytes to subcutaneously administered pneumococcal vaccine was studied in five patients without spleens and in five healthy subjects. Seven days after immunisation circulating B cells synthesising IgG antipneumococcal capsular polysaccharides (anti-PCP) appeared in both groups. Twenty one days after vaccination this B cell population had disappeared and a B cell subs...

Production and standardization of polyvalent Clostridium perfringens vaccine in Iran.

In this presentation an account of the large-scale production and the standardization of polyvalent Clostridium perfringens vaccine in Iran is described. Over 20 million doses of this vaccine are produced and utilized in Iran every year. Certain modifications have been made to the culture media used in our laboratory for the production of this vaccine in order to bring down its cost. The prepar...